?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F18607%2F&rft.title=Synthesis+of+Pyrrolo%5B1%2C3%5D-Diazepines+and+Potential+Poxvirus+Resolvase+Inhibitors&rft.creator=Parks%2C+Brandon&rft.description=This+thesis+describes+our+efforts+toward+the+development+of+a+dynamic+combinatorial+library+using+pyrrolo%5B1%2C3%5D-diazepines.+During+our+work%2C+I+have+demonstrated+the+ability+to+hydrolyze+and+recyclize+the+diazepine+core+via+the+condensation+of+several+different+aldehydes+to+afford+novel+diazepine+derivatives.+Additionally%2C+I+have+been+able+to+modulate+the+electronic+and+steric+properties+of+the+diazepine+scaffold+through+substitution+on+the+pyrrole+core.+My+work+towards+finding+suitable+conditions+for+a+thermodynamically+controlled+dynamic+exchange+reaction+have+shown+that+while+hydrolysis+of+the+diazepine+scaffold+seems+to+be+favored%2C+recyclization+of+the+resulting+amine+intermediate+appears+to+be+disfavored.+As+a+second+project+I+describe+our+efforts+toward+the+development+of+a+library+of+pyrimidinone-based+potential+poxvirus+resolvase+inhibitors.+Utilizing+the+multi-component+Biginelli+reaction%2C+I+have+synthesized+a+small+library+of+pyrimidinones+attached+to+potential+chelating+functionalities%2C+including+the+di-keto+acid+moiety.+Biological+testing+has+resulted+in+the+discovery+of+a+carboxylic+acid+containing+pyrimidinone+(MAL1-265)+that+possesses+moderate+fowlpox+resolvase+inhibitory+activity+(IC50+16+%CE%BCM).&rft.date=2013-07-01&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F18607%2F4%2Fb_parks_ETD.pdf&rft.identifier=++Parks%2C+Brandon++(2013)+Synthesis+of+Pyrrolo%5B1%2C3%5D-Diazepines+and+Potential+Poxvirus+Resolvase+Inhibitors.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++