%0 Journal Article
%@ 1523-7060
%A Moura-Letts, G
%A Curran, DP
%D 2007
%F pittir:18573
%J Organic Letters
%N 1
%P 5 - 8
%T Selective synthesis of (2Z,4E)-dienyl esters by ene-diene cross metathesis
%U http://d-scholarship-dev.library.pitt.edu/18573/
%V 9
%X (Chemical Equation Presented) Cross metathesis of terminal alkenes with methyl (2Z4E)-hexadienoate and related dienyl esters provides substituted (2Z,4E)-dienyl esters in good yields. Small-scale reactions are effectively promoted by the standard second-generation Grubbs-Hoveyda catalyst (GH-II), while a new fluorous GH-II catalyst is used for separation and recovery in gram-scale reactions. The transformation is featured in a rapid synthesis of the bottom fragments of the potent anticancer agents (-)-dictyostatin and 6-epi-dictyostatin. © 2007 American Chemical Society.