%A C Del Pozo
%A AI Keller
%A T Nagashima
%A DP Curran
%J Organic Letters
%T Amide bond formation with a new fluorous carbodiimide: Separation by reverse fluorous solid-phase extraction
%X A new fluorous carbodiimide is introduced along with a convenient procedure for amide coupling reactions. Reactions of acids and amines under standard conditions for carbodiimide couplings, followed by simple reverse fluorous solid-phase extraction (FSPE) over standard silica gel, provide the target amide products in good yields and purities. The use of HFE-7100 as a fluorous solvent is crucial for the success of the reverse FSPE. ? 2007 American Chemical Society.
%N 21
%P 4167 - 4170
%V 9
%D 2007
%R 10.1021/ol701631m
%L pittir18198