%A WH Jung
%A S Guyenne
%A C Riesco-Fagundo
%A J Mancuso
%A S Nakamura
%A DP Curran
%J Angewandte Chemie - International Edition
%T Confirmation of the stereostructure of (+)-cytostatin by fluorous mixture synthesis of four candidate stereoisomers
%X Mix and match: Four closely related candidate isomers for cytostatin have been synthesized by using the technique of fluorous mixture synthesis. Comparison of NMR, thin-layer chromatography, and optical rotation data enabled the three isomers that were not cytostatin to be identified. Thus, by a process of elimination (disproof), the isomer corresponding to cytostatin was determined, and the 4S,5S,6S,9S,10S,11S configuration confirmed. (Chemical Equation Presented). ? 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
%N 6
%P 1130 - 1133
%V 47
%D 2008
%R 10.1002/anie.200704893
%L pittir18101