?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F17960%2F&rft.title=Synthetic+Studies+of+Meloscine+and+Related+Alkaloids&rft.creator=Zhang%2C+Hanmo&rft.description=The+first+section+of+this+dissertation+describes+the+discovery+and+studies+of+new+radical+desulfonylation+reactions.+These+reactions+allow+convenient+access+to+structurally+diverse+imines+under+mild+conditions.+We+have+examined+several+related+desulfonylation+reactions%2C+and+the+results+of+this+investigation+support+the+general+mechanism+that+we+initially+proposed.%0D%0AThe+second+section+details+the+synthesis+of+(%C2%B1)-epimeloscine%2C+(%C2%B1)-meloscine%2C+and+analogs.+The+invention+of+a+novel%2C+cascade+radical+annulation+of+divinylcyclopropanes+enables+expedient+synthesis+of+(%C2%B1)-epimeloscine+and+(%C2%B1)-meloscine%2C+and+analogs.+Preliminary+studies+on+a+chirality+transfer+approach+towards+(%2B)-meloscine+are+discussed.+This+approach+delivered+only+moderate+chirality+transfer%2C+however%2C+a+new+cascade+cope%2Fene+reaction+was+discovered+along+the+way.%0D%0A&rft.date=2013-07-02&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F17960%2F4%2FHanmo_Zhang_ETD_4-17-2013.pdf&rft.identifier=++Zhang%2C+Hanmo++(2013)+Synthetic+Studies+of+Meloscine+and+Related+Alkaloids.++Doctoral+Dissertation%2C+University+of+Pittsburgh.++++(Unpublished)++