<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Chemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis"^^ . "This thesis describes the synthesis of several small molecules, structurally related to SID3712502, which have shown promise as inhibitors of castration-resistant prostate cancer by preventing nuclear translocation of the androgen receptor. This thesis also describes the preparation of a small library of α- and β-glycoslyated analogs of N-acetylglucosamine and N-acetylgalactosamine, which were prepared from an oxazoline intermediate or by an acid catalyzed isomerization with the desired glycosyl acceptors. The configuration of the lead compound, C34, was confirmed by synthesis and NMR studies. Four glucosamine analogs and two galactosamine analogs showed promising in vitro anti-inflammatory effects. These analogs were shown to be probes for reducing cytokine over-expression through inhibition of TLR4 and able to reduce the gross disease of necrotizing enterocolitis."^^ . "2013-06-30" . . . . . . . . "Benjamin R."^^ . "Eyer"^^ . "Benjamin R. Eyer"^^ . . . . . . "Chemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis (PDF)"^^ . . . . . . "ETD_Benjamin_Richard_Eyer_Pitt2013_CorrectedFinal.pdf"^^ . . . "Chemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . . "Chemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis (Other)"^^ . . . . . . "Chemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis (Other)"^^ . . . . . . "Chemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis (Other)"^^ . . . . . . "Chemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis (Other)"^^ . . . . . "HTML Summary of #17424 \n\nChemical Probes for the Treatment of Castration-Resistant Prostate Cancer and Necrotizing Enterocolitis\n\n" . "text/html" . .