?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F17424%2F&rft.title=Chemical+Probes+for+the+Treatment+of+Castration-Resistant+Prostate+Cancer+and+Necrotizing+Enterocolitis&rft.creator=Eyer%2C+Benjamin+R.&rft.description=This+thesis+describes+the+synthesis+of+several+small+molecules%2C+structurally+related+to+SID3712502%2C+which+have+shown+promise+as+inhibitors+of+castration-resistant+prostate+cancer+by+preventing+nuclear+translocation+of+the+androgen+receptor.+This+thesis+also+describes+the+preparation+of+a+small+library+of+%CE%B1-+and+%CE%B2-glycoslyated+analogs+of+N-acetylglucosamine+and+N-acetylgalactosamine%2C+which+were+prepared+from+an+oxazoline+intermediate+or+by+an+acid+catalyzed+isomerization+with+the+desired+glycosyl+acceptors.+The+configuration+of+the+lead+compound%2C+C34%2C+was+confirmed+by+synthesis+and+NMR+studies.+Four+glucosamine+analogs+and+two+galactosamine+analogs+showed+promising+in+vitro+anti-inflammatory+effects.+These+analogs+were+shown+to+be+probes+for+reducing+cytokine+over-expression+through+inhibition+of+TLR4+and+able+to+reduce+the+gross+disease+of+necrotizing+enterocolitis.&rft.date=2013-06-30&rft.type=University+of+Pittsburgh+ETD&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.identifier=http%3A%2F%2Fd-scholarship-dev.library.pitt.edu%2F17424%2F1%2FETD_Benjamin_Richard_Eyer_Pitt2013_CorrectedFinal.pdf&rft.identifier=++Eyer%2C+Benjamin+R.++(2013)+Chemical+Probes+for+the+Treatment+of+Castration-Resistant+Prostate+Cancer+and+Necrotizing+Enterocolitis.++Master's+Thesis%2C+University+of+Pittsburgh.++++(Unpublished)++