eprintid: 17388
rev_number: 16
userid: 1419
dir: disk0/00/01/73/88
datestamp: 2013-02-27 18:35:51
lastmod: 2019-02-02 16:55:07
status_changed: 2013-02-27 18:35:51
type: article
metadata_visibility: show
item_issues_count: 0
eprint_status: archive
creators_name: Mikhonin, AV
creators_name: Ahmed, Z
creators_name: Ianoul, A
creators_name: Asher, SA
creators_email: 
creators_email: 
creators_email: 
creators_email: asher@pitt.edu
creators_id: 
creators_id: 
creators_id: 
creators_id: ASHER
title: Assignments and conformational dependencies of the amide III peptide backbone UV resonance Raman bands
ispublished: pub
divisions: sch_as_chemistry
full_text_status: public
abstract: We investigated the assignments and the conformational dependencies of the UV resonance Raman bands of the 21-residue mainly alanine peptide (AP) and its isotopically substituted derivatives in both their α-helical and PPII states. We also examined smaller peptides to correlate conformation, hydrogen bonding, and structure. Our vibrational mode analysis confirms the complex nature of the amide III region, which contains many vibrational modes. We assign these bands by interpreting the isotopically induced frequency shifts and the conformational sensitivity of these bands and their temperature dependence. Our assignments of the amide bands in some cases agree, but in other cases challenge previous assignments by Lee and Krimm (Biopolymers 1998, 46, 283-317), Overman and Thomas (Biochemistry 1998, 37, 5654-5665), and Diem et al. (J. Phys. Chem. 1992, 96, 548-554). We see evidence for the partial dehydration of α-helices at elevated temperatures.
date: 2004-12-09
date_type: published
publication: Journal of Physical Chemistry B
volume: 108
number: 49
pagerange: 19020 - 19028
refereed: TRUE
issn: 1520-6106
id_number: 10.1021/jp045959d
citation:   Mikhonin, AV and Ahmed, Z and Ianoul, A and Asher, SA  (2004) Assignments and conformational dependencies of the amide III peptide backbone UV resonance Raman bands.  Journal of Physical Chemistry B, 108 (49).  19020 - 19028.  ISSN 1520-6106     
document_url: http://d-scholarship-dev.library.pitt.edu/17388/1/licence.txt