TY  - JOUR
ID  - pittir17246
UR  - http://d-scholarship-dev.library.pitt.edu/17246/
IS  - 15
A1  - Xiong, K
A1  - Asher, SA
Y1  - 2010/04/20/
N2  - We used CD and UV resonance Raman spectroscopy to study the impact of alcohols on the conformational equilibria and relative Gibbs free energy landscapes along the Ramachandran ?-coordinate of a mainly poly-Ala peptide, AP with an AAAAA(AAARA)3A sequence. 2,2,2-Trifluoroethanol (TFE) most stabilizes the ?-helix-like conformations, followed by ethanol, methanol, and pure water. The ?-bulge conformation is stabilized more than the ?-helix, while the 310-helix is destabilized due to the alcohol-increased hydrophobicity. Turns are also stabilized by alcohols. We also found that while TFE induces more ?-helices, it favors multiple, shorter helix segments. © 2010 American Chemical Society.
JF  - Biochemistry
VL  - 49
SN  - 0006-2960
TI  - Circular dichroism and UV resonance raman study of the impact of alcohols on the gibbs free energy landscape of an ?-helical peptide
SP  - 3336 
AV  - public
EP  -  3342
ER  -