%0 Generic
%9 Doctoral Dissertation
%A Buck, Eric
%D 2013
%F pittir:16753
%K anatoxin-a(s), guanidine, 
%T SYNTHETIC STUDIES TOWARDS THE SYNTHESIS OF ANATOXIN-A(S)
%U http://d-scholarship-dev.library.pitt.edu/16753/
%X Three routes toward the total synthesis of the neurotoxin anatoxin-a(s) have been explored. They focus on the assembly of the backbone utilizing both Pd(0)- and Pd(II)-mediated processes. Our current route leads to a late-stage precursor of anatoxin-a(s), hydroxy guanidine 134, in 18 steps and in 8.0% overall yield utilizing an amidoalkylation step in the key cyclization.