relation: http://d-scholarship-dev.library.pitt.edu/16753/
title: SYNTHETIC STUDIES TOWARDS THE SYNTHESIS OF ANATOXIN-A(S)
creator: Buck, Eric
description: Three routes toward the total synthesis of the neurotoxin anatoxin-a(s) have been explored. They focus on the assembly of the backbone utilizing both Pd(0)- and Pd(II)-mediated processes. Our current route leads to a late-stage precursor of anatoxin-a(s), hydroxy guanidine 134, in 18 steps and in 8.0% overall yield utilizing an amidoalkylation step in the key cyclization.
date: 2013-01-25
type: University of Pittsburgh ETD
type: PeerReviewed
format: application/pdf
language: en
identifier: http://d-scholarship-dev.library.pitt.edu/16753/1/Buck-Thesis.pdf
identifier:   Buck, Eric  (2013) SYNTHETIC STUDIES TOWARDS THE SYNTHESIS OF ANATOXIN-A(S).  Doctoral Dissertation, University of Pittsburgh.    (Unpublished)