@unpublished{pittir16753, month = {January}, title = {SYNTHETIC STUDIES TOWARDS THE SYNTHESIS OF ANATOXIN-A(S)}, author = {Eric Buck}, year = {2013}, keywords = {anatoxin-a(s), guanidine, }, url = {http://d-scholarship-dev.library.pitt.edu/16753/}, abstract = {Three routes toward the total synthesis of the neurotoxin anatoxin-a(s) have been explored. They focus on the assembly of the backbone utilizing both Pd(0)- and Pd(II)-mediated processes. Our current route leads to a late-stage precursor of anatoxin-a(s), hydroxy guanidine 134, in 18 steps and in 8.0\% overall yield utilizing an amidoalkylation step in the key cyclization.} }