@article{pittir14166,
          volume = {7},
          number = {3},
           month = {March},
           title = {Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice},
          author = {AA Shvedova and AA Kapralov and WH Feng and ER Kisin and AR Murray and RR Mercer and CM St. Croix and MA Lang and SC Watkins and NV Konduru and BL Allen and J Conroy and GP Kotchey and BM Mohamed and AD Meade and Y Volkov and A Star and B Fadeel and VE Kagan},
            year = {2012},
         journal = {PLoS ONE},
             url = {http://d-scholarship-dev.library.pitt.edu/14166/},
        abstract = {Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and pro-inflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. Our results provide direct evidence for the participation of MPO - one of the key-orchestrators of inflammatory response - in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of nanomaterials through genetic or pharmacological manipulations. {\copyright} 2012.}
}