<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Origin and dynamics of HIV-1 subtype c infection in India"^^ . "Objective: To investigate the geographical origin and evolution dynamics of HIV-1 subtype C infection in India. Design: Ninety HIV-1 subtype C env gp120 subtype C sequences from India were compared with 312 env gp120 reference subtype C sequences from 27 different countries obtained from Los Alamos HIV database. All the HIV-1 subtype C env gp120 sequences from India were used for the geographical origin analysis and 61 subtype C env gp120 sequences with known sampling year (from 1991 to 2008) were employed to determine the origin of HIV infection in India. Methods: Phylogenetic analysis of HIV-1 env sequences was used to investigate the geographical origin and tMRCA of Indian HIV-1 subtype C. Evolutionary parameters including origin date and demographic growth patterns of Indian subtype C were estimated using a Bayesian coalescent-based approach under relaxed molecular clock models. Findings: The majority of the analyzed Indian and South African HIV-1 subtype C sequences formed a single monophyletic cluster. The most recent common ancestor date was calculated to be 1975.56 (95% HPD, 1968.78-1981.52). Reconstruction of the effective population size revealed three phases of epidemic growth: an initial slow growth, followed by exponential growth, and then a plateau phase approaching present time. Stabilization of the epidemic growth phase correlated with the foundation of National AIDS Control Organization in India. Interpretation: Indian subtype C originated from a single South African lineage in the middle of 1970s. The current study emphasizes not only the utility of HIV-1 sequence data for epidemiological studies but more notably highlights the effectiveness of community or government intervention strategies in controlling the trend of the epidemic. © 2011 Shen et al."^^ . "2011-10-10" . . . "6" . "10" . . "PLoS ONE"^^ . . . . . . . . . . . . . . . . . . . . . "M"^^ . "Ding"^^ . "M Ding"^^ . . "David"^^ . "Harrich"^^ . "David Harrich"^^ . . "Y"^^ . "Chen"^^ . "Y Chen"^^ . . "C"^^ . "Shen"^^ . "C Shen"^^ . . "J"^^ . "Craigo"^^ . "J Craigo"^^ . . "P"^^ . "Gupta"^^ . "P Gupta"^^ . . . . . . "Origin and dynamics of HIV-1 subtype c infection in India (PDF)"^^ . . . . . . . . "Origin_and_Dynamics.pdf"^^ . . . "Origin and dynamics of HIV-1 subtype c infection in India (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . . "Origin and dynamics of HIV-1 subtype c infection in India (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Origin and dynamics of HIV-1 subtype c infection in India (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Origin and dynamics of HIV-1 subtype c infection in India (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Origin and dynamics of HIV-1 subtype c infection in India (Other)"^^ . . . . . . "small.jpg"^^ . . . "Origin and dynamics of HIV-1 subtype c infection in India (Plain Text)"^^ . . . "licence.txt"^^ . . . "Origin and dynamics of HIV-1 subtype c infection in India (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #13981 \n\nOrigin and dynamics of HIV-1 subtype c infection in India\n\n" . "text/html" . .