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primary topic: Common genetic variation and the control of HIV-1 in humans

Common genetic variation and the control of HIV-1 in humans
type: AcademicArticle
type: Article
abstract: To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
date: 2009-12-01
volume: 5
issue: 12
is part of: PLoS Genetics
status: peerReviewed
status: published
author list: authors
creator: JJ Martinson
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Common genetic variation and the control of HIV-1 in humans (PDF)
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has published: Common genetic variation and the control of HIV-1 in humans (PDF)
has document: Common genetic variation and the control of HIV-1 in humans (Indexer Terms)
has document: Common genetic variation and the control of HIV-1 in humans (Other)
has document: Common genetic variation and the control of HIV-1 in humans (Plain Text)

Common genetic variation and the control of HIV-1 in humans (PDF)
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has volatile version: Common genetic variation and the control of HIV-1 in humans (Indexer Terms)
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Common genetic variation and the control of HIV-1 in humans (Plain Text)
type: Document
has file: licence.txt
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PLoS Genetics
type: Collection
issn: 15537390

Mark I. McCarthy
type: Person
given name: Mark I.
family name: McCarthy

JJ Martinson
type: Person
given name: JJ
family name: Martinson

K Zhang
type: Person
given name: K
family name: Zhang

CE Gumbs
type: Person
given name: CE
family name: Gumbs

TJ Urban
type: Person
given name: TJ
family name: Urban

AJ McMichael
type: Person
given name: AJ
family name: McMichael

A Castagna
type: Person
given name: A
family name: Castagna

R Detels
type: Person
given name: R
family name: Detels

C Mussini
type: Person
given name: C
family name: Mussini

D Ge
type: Person
given name: D
family name: Ge

JP Smith
type: Person
given name: JP
family name: Smith

A Telenti
type: Person
given name: A
family name: Telenti

JM Miro
type: Person
given name: JM
family name: Miro

J Fellay
type: Person
given name: J
family name: Fellay

S Feng
type: Person
given name: S
family name: Feng

J Dalmau
type: Person
given name: J
family name: Dalmau

S Colombo
type: Person
given name: S
family name: Colombo

P Easterbrook
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given name: P
family name: Easterbrook

KV Shianna
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given name: KV
family name: Shianna

SM Wolinsky
type: Person
given name: SM
family name: Wolinsky

P Descombes
type: Person
given name: P
family name: Descombes

S Mallal
type: Person
given name: S
family name: Mallal

HF Günthard
type: Person
given name: HF
family name: Günthard

SE Antonarakis
type: Person
given name: SE
family name: Antonarakis

NL Letvin
type: Person
given name: NL
family name: Letvin

N Obel
type: Person
given name: N
family name: Obel

JS Beckmann
type: Person
given name: JS
family name: Beckmann

DB Goldstein
type: Person
given name: DB
family name: Goldstein

JB Margolick
type: Person
given name: JB
family name: Margolick

BF Haynes
type: Person
given name: BF
family name: Haynes

A De Luca
type: Person
given name: A
family name: De Luca

J Martinez-Picado
type: Person
given name: J
family name: Martinez-Picado

ET Cirulli
type: Person
given name: ET
family name: Cirulli

B Ledergerber
type: Person
given name: B
family name: Ledergerber

LP Jacobson
type: Person
given name: LP
family name: Jacobson

M Carrington
type: Person
given name: M
family name: Carrington

SJ O'Brien
type: Person
given name: SJ
family name: O'Brien

A Cozzi-Lepri
type: Person
given name: A
family name: Cozzi-Lepri

Common genetic variation and the control of HIV-1 in humans (Indexer Terms)
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Common genetic variation and the control of HIV-1 in humans (Other)
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Common genetic variation and the control of HIV-1 in humans (Other)
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Common genetic variation and the control of HIV-1 in humans (Other)
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primary topic: Common genetic variation and the control of HIV-1 in humans