relation: http://d-scholarship-dev.library.pitt.edu/13304/
title: Common genetic variation and the control of HIV-1 in humans
creator: Fellay, J
creator: Ge, D
creator: Shianna, KV
creator: Colombo, S
creator: Ledergerber, B
creator: Cirulli, ET
creator: Urban, TJ
creator: Zhang, K
creator: Gumbs, CE
creator: Smith, JP
creator: Castagna, A
creator: Cozzi-Lepri, A
creator: De Luca, A
creator: Easterbrook, P
creator: Günthard, HF
creator: Mallal, S
creator: Mussini, C
creator: Dalmau, J
creator: Martinez-Picado, J
creator: Miro, JM
creator: Obel, N
creator: Wolinsky, SM
creator: Martinson, JJ
creator: Detels, R
creator: Margolick, JB
creator: Jacobson, LP
creator: Descombes, P
creator: Antonarakis, SE
creator: Beckmann, JS
creator: O'Brien, SJ
creator: Letvin, NL
creator: McMichael, AJ
creator: Haynes, BF
creator: Carrington, M
creator: Feng, S
creator: Telenti, A
creator: Goldstein, DB
description: To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
date: 2009-12-01
type: Article
type: PeerReviewed
format: application/pdf
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/13304/1/Common_Genetic_Variation.pdf
format: text/plain
language: en
rights: attached
identifier: http://d-scholarship-dev.library.pitt.edu/13304/8/licence.txt
identifier:   Fellay, J and Ge, D and Shianna, KV and Colombo, S and Ledergerber, B and Cirulli, ET and Urban, TJ and Zhang, K and Gumbs, CE and Smith, JP and Castagna, A and Cozzi-Lepri, A and De Luca, A and Easterbrook, P and Günthard, HF and Mallal, S and Mussini, C and Dalmau, J and Martinez-Picado, J and Miro, JM and Obel, N and Wolinsky, SM and Martinson, JJ and Detels, R and Margolick, JB and Jacobson, LP and Descombes, P and Antonarakis, SE and Beckmann, JS and O'Brien, SJ and Letvin, NL and McMichael, AJ and Haynes, BF and Carrington, M and Feng, S and Telenti, A and Goldstein, DB  (2009) Common genetic variation and the control of HIV-1 in humans.  PLoS Genetics, 5 (12).   ISSN 1553-7390     
relation: 10.1371/journal.pgen.1000791