eprintid: 13281
rev_number: 17
userid: 677
importid: 499
dir: disk0/00/01/32/81
datestamp: 2012-08-03 16:33:27
lastmod: 2019-01-29 15:56:01
status_changed: 2012-08-03 16:33:27
type: article
metadata_visibility: show
contact_email: mtmpjb@gwumc.edu
item_issues_count: 0
eprint_status: archive
creators_name: Brindley, PJ
creators_name: Mitreva, M
creators_name: Ghedin, E
creators_name: Lustigman, S
creators_email: 
creators_email: 
creators_email: elg21@pitt.edu
creators_email: 
creators_id: 
creators_id: 
creators_id: ELG21
creators_id: 
contributors_type: http://www.loc.gov/loc.terms/relators/EDT
contributors_name: Knight, Matty
title: Helminth genomics: The implications for human health
ispublished: pub
divisions: sch_gsph_infectiousdiseasesmicrobiology
full_text_status: public
abstract: More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, loss of productivity among the workforce, and maintenance of poverty. Genomes of the major helminth species that affect humans, and many others of agricultural and veterinary significance, are now the subject of intensive genome sequencing and annotation. Draft genome sequences of the filarial worm Brugia malayi and two of the human schistosomes, Schistosoma japonicum and S. mansoni, are now available, among others. These genome data will provide the basis for a comprehensive understanding of the molecular mechanisms involved in helminth nutrition and metabolism, host-dependent development and maturation, immune evasion, and evolution. They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings. © 2009 Brindley et al.
date: 2009-10-01
date_type: published
publication: PLoS Neglected Tropical Diseases
volume: 3
number: 10
refereed: TRUE
id_number: 10.1371/journal.pntd.0000538
article_type: review
other_id: NLM PMC2757907
pmcid: PMC2757907
pmid: 19855829
mesh_headings: Animals
mesh_headings: Genome, Helminth
mesh_headings: Genomics
mesh_headings: Helminthiasis--immunology
mesh_headings: Helminthiasis--parasitology
mesh_headings: Helminths--classification
mesh_headings: Helminths--genetics
mesh_headings: Helminths--immunology
mesh_headings: Host-Parasite Interactions
mesh_headings: Humans
mesh_headings: Phylogeny
citation:   Brindley, PJ and Mitreva, M and Ghedin, E and Lustigman, S  (2009) Helminth genomics: The implications for human health.  PLoS Neglected Tropical Diseases, 3 (10).       
document_url: http://d-scholarship-dev.library.pitt.edu/13281/1/Helminth_Genomics.pdf
document_url: http://d-scholarship-dev.library.pitt.edu/13281/8/licence.txt