eprintid: 11811 rev_number: 55 userid: 808 dir: disk0/00/01/18/11 datestamp: 2012-06-21 13:37:41 lastmod: 2016-11-15 13:57:26 status_changed: 2012-06-21 13:37:40 type: thesis_degree metadata_visibility: show contact_email: lkhwang@gmail.com item_issues_count: 0 eprint_status: archive creators_name: Hwang, Leekyoung creators_email: leh35@pitt.edu creators_id: LEH35 title: DEVELOPMENT AND MECHANISTIC STUDY OF A PEPTIDE BASED METHODOLOGY FOR THE PREPARATION OF NANOPARTICLE SUPERSTRUCTURES ispublished: unpub divisions: sch_as_chemistry full_text_status: public keywords: Biomimetic synthesis; peptides; self-assembly; nanoparticles; nanoparticle assembly abstract: The aim of this research is to develop and generalize a peptide-based methodology for inorganic nanoparticle assembly and to understand the underlying mechanism governing the synthesis and assembly process. This research is based on a new methodology to synthesize complex and well-organized nanoparticle superstructures that the Rosi group has developed. This method relies on the use of peptide conjugate molecules to direct both synthesis and the assembly of the nanoparticles. To accomplish goals of this research, new peptide conjugates were designed and synthesized in order to program substantial amounts of information into the peptide conjugate molecules. Their self-assembly has been studied and their ability to direct nanoparticle synthesis and self-assembly has been studied. The research details how modifications to the peptide sequence can impact the resulting structure formation. Fundamental studies were also performed to understand the mechanistic factors underlying this methodology. The key criteria for preparing highly-ordered nanoparticle superstructures were also investigated using this methodology. Ultimately, this approach will lead to precise control over the shape, composition, and interparticle distance within nanoparticle superstructures. date: 2012-06-21 date_type: published pages: 132 institution: University of Pittsburgh refereed: TRUE etdcommittee_type: committee_chair etdcommittee_type: committee_member etdcommittee_type: committee_member etdcommittee_type: committee_member etdcommittee_name: Rosi, Nathaniel etdcommittee_name: Meyer, Tara etdcommittee_name: Star, Alexander etdcommittee_name: Lee, Jung-Kun etdcommittee_email: nrosi@pitt.edu etdcommittee_email: tmeyer@pitt.edu etdcommittee_email: astar@pitt.edu etdcommittee_email: jul37@pitt.edu etdcommittee_id: NROSI etdcommittee_id: TMEYER etdcommittee_id: ASTAR etdcommittee_id: JUL37 etd_defense_date: 2012-04-17 etd_approval_date: 2012-06-21 etd_submission_date: 2012-04-16 etd_release_date: 2012-06-21 etd_access_restriction: 1_year etd_patent_pending: FALSE assigned_doi: doi:10.5195/pitt.etd.2012.11811 thesis_type: dissertation degree: PhD citation: Hwang, Leekyoung (2012) DEVELOPMENT AND MECHANISTIC STUDY OF A PEPTIDE BASED METHODOLOGY FOR THE PREPARATION OF NANOPARTICLE SUPERSTRUCTURES. Doctoral Dissertation, University of Pittsburgh. (Unpublished) document_url: http://d-scholarship-dev.library.pitt.edu/11811/1/Thesis_PhD_Leekyoung_Hwang_FINAL.pdf