<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Development and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions"^^ . "Iridium(I)-catalyzed olefin isomerization in bis(allyl) ethers is integrated into a generally applicable strategy for affecting highly stereoselective Claisen rearrangements. Catalyzed alkene isomerization affords allyl vinyl ethers from easily prepared di(allyl) ethers; direct thermolysis of these reaction mixtures leads to highly diastereoselective [3,3] sigmatropic rearrangements affording syn-2,3-dialkyl-4-pentenal derivatives. An easily executed strategy for realizing asymmetric variants of the isomerization-Claisen rearrangement (ICR) reactions is also described.Merging the catalytic asymmetric synthesis of di(allyl) ethers with ensuing olefin isomerization-Claisen rearrangement (ICR) reactions provides a convenient, two-step route to asymmetric aliphatic Claisen rearrangements from easily obtained starting materials. These reactions deliver the 2,3-disubstituted 4-pentenal derivatives characteristic of aliphatic Claisen rearrangements with excellent relative and absolute stereocontrol. A catalytic enantioselective synthesis of the (+)-calopin dimethyl ether demonstrates the utility of this reaction technology in asymmetric synthesis enterprises.Stereoselective quaternary all-carbon stereocenter construction is often not easily achieved from methodologies developed primarily for accessing less substituted stereogenic carbons. Olefin isomerization-Claisen rearrangement (ICR) reactions offer a strategy for recruiting the venerable Claisen rearrangement for asymmetric quaternary carbon construction. Several complementary strategies for enantioselective quaternary carbon synthesis derive directly from the ICR reaction design."^^ . "2008-01-29" . . . . . . . . "Kan"^^ . "Wang"^^ . "Kan Wang"^^ . . . . . . "Development and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions (PDF)"^^ . . . . . . "wangkanfinal2_etd.pdf"^^ . . . "Development and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . . "Development and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Development and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Development and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Development and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #10439 \n\nDevelopment and Synthesis Applications of Olefin Isomerization-Claisen Rearrangement Reactions\n\n" . "text/html" . .