Stebbins, S and Cummings, DAT and Stark, JH and Vukotich, C and Mitruka, K and Thompson, W and Rinaldo, C and Roth, L and Wagner, M and Wisniewski, SR and Dato, V and Eng, H and Burke, DS
(2011)
Reduction in the incidence of influenza A but not influenza B associated with use of hand sanitizer and cough hygiene in schools: A randomized controlled trial.
Pediatric Infectious Disease Journal, 30 (11).
921 - 926.
ISSN 0891-3668
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Abstract
Background: Laboratory-based evidence is lacking regarding the efficacy of nonpharmaceutical interventions (NPIs) such as alcohol-based hand sanitizer and respiratory hygiene to reduce the spread of influenza. Methods: The Pittsburgh Influenza Prevention Project was a cluster-randomized trial conducted in 10 elementary schools in Pittsburgh, PA, during the 2007 to 2008 influenza season. Children in 5 intervention schools received training in hand and respiratory hygiene, and were provided and encouraged to use hand sanitizer regularly. Children in 5 schools acted as controls. Children with influenza-like illness were tested for influenza A and B by reverse-transcriptase polymerase chain reaction. Results: A total of 3360 children participated in this study. Using reverse-transcriptase polymerase chain reaction, 54 cases of influenza A and 50 cases of influenza B were detected. We found no significant effect of the intervention on the primary study outcome of all laboratory-confirmed influenza cases (incidence rate ratio [IRR]: 0.81; 95% confidence interval [CI]: 0.54, 1.23). However, we did find statistically significant differences in protocol-specified ancillary outcomes. Children in intervention schools had significantly fewer laboratory-confirmed influenza A infections than children in control schools, with an adjusted IRR of 0.48 (95% CI: 0.26, 0.87). Total absent episodes were also significantly lower among the intervention group than among the control group; adjusted IRR 0.74 (95% CI: 0.56, 0.97). Conclusions: NPIs (respiratory hygiene education and the regular use of hand sanitizer) did not reduce total laboratory-confirmed influenza. However, the interventions did reduce school total absence episodes by 26% and laboratory-confirmed influenza A infections by 52%. Our results suggest that NPIs can be an important adjunct to influenza vaccination programs to reduce the number of influenza A infections among children. © 2011 by Lippincott Williams & Wilkins.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
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Stebbins, S | | | | Cummings, DAT | | | | Stark, JH | | | | Vukotich, C | | | | Mitruka, K | | | | Thompson, W | | | | Rinaldo, C | RINALDO@pitt.edu | RINALDO | | Roth, L | | | | Wagner, M | | | | Wisniewski, SR | STEVEWIS@pitt.edu | STEVEWIS | | Dato, V | vmd11@pitt.edu | VMD11 | | Eng, H | HENG@pitt.edu | HENG | | Burke, DS | donburke@pitt.edu | DONBURKE | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Center for Public Health Practice Other Centers, Institutes, Offices, or Units > Center for Vaccine Research |
Date: |
1 January 2011 |
Date Type: |
Publication |
Journal or Publication Title: |
Pediatric Infectious Disease Journal |
Volume: |
30 |
Number: |
11 |
Page Range: |
921 - 926 |
DOI or Unique Handle: |
10.1097/inf.0b013e3182218656 |
Schools and Programs: |
School of Public Health > Epidemiology School of Public Health > Infectious Diseases and Microbiology |
Refereed: |
Yes |
ISSN: |
0891-3668 |
Date Deposited: |
07 May 2015 20:03 |
Last Modified: |
18 May 2020 13:56 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/24366 |
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