Wipf, P and Pierce, JG and Wang, X
(2003)
Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions.
Tetrahedron Asymmetry, 14 (22).
3605 - 3611.
ISSN 0957-4166
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Abstract
The recently developed (cyclohexylsulfonylamino)oxazoline (CHAOx) ligand was found to provide high ee's and consistent reaction rates in the asymmetric diethylzinc addition to benzaldehyde over a remarkably large loading range of 0.05-10 mol%. Turnover numbers of 1000-2000 can be explained by the absence of a nonlinear effect and the formation of a catalytically active monomer complex. Substituents at the nitrogen donor atoms of the bidentate ligand prevent zinc-complex dimerization. © 2003 Elsevier Ltd. All rights reserved.
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