LaValle, CR and George, KM and Sharlow, ER and Lazo, JS and Wipf, P and Wang, QJ
(2010)
Protein kinase D as a potential new target for cancer therapy.
Biochimica et Biophysica Acta - Reviews on Cancer, 1806 (2).
183 - 192.
ISSN 0304-419X
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Abstract
Protein kinase D is a novel family of serine/threonine kinases and diacylglycerol receptors that belongs to the calcium/calmodulin-dependent kinase superfamily. Evidence has established that specific PKD isoforms are dysregulated in several cancer types, and PKD involvement has been documented in a variety of cellular processes important to cancer development, including cell growth, apoptosis, motility, and angiogenesis. In light of this, there has been a recent surge in the development of novel chemical inhibitors of PKD. This review focuses on the potential of PKD as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of PKD inhibitors. © 2010 Elsevier B.V.
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Details
Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
---|
LaValle, CR | | | | George, KM | | | | Sharlow, ER | | | | Lazo, JS | | | | Wipf, P | pwipf@pitt.edu | PWIPF | | Wang, QJ | | | |
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Date: |
1 December 2010 |
Date Type: |
Publication |
Journal or Publication Title: |
Biochimica et Biophysica Acta - Reviews on Cancer |
Volume: |
1806 |
Number: |
2 |
Page Range: |
183 - 192 |
DOI or Unique Handle: |
10.1016/j.bbcan.2010.05.003 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0304-419X |
Article Type: |
Review |
MeSH Headings: |
Cell Movement; Humans; Neoplasm Invasiveness; Neoplasms--drug therapy; Neoplasms--enzymology; Neoplasms--pathology; Protein Kinase C--analysis; Protein Kinase C--antagonists & inhibitors; Protein Kinase Inhibitors--therapeutic use; Signal Transduction |
Other ID: |
NLM NIHMS208514, NLM PMC2947595 |
PubMed Central ID: |
PMC2947595 |
PubMed ID: |
20580776 |
Date Deposited: |
18 Jul 2014 21:18 |
Last Modified: |
02 Feb 2019 15:57 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/22224 |
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