Kanai, A and Zabbarova, I and Amoscato, A and Epperly, M and Xiao, J and Wipf, P
(2007)
Mitochondrial targeting of radioprotectants using peptidyl conjugates.
Organic and Biomolecular Chemistry, 5 (2).
307 - 309.
ISSN 1477-0520
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Abstract
Ionizing radiation activates a mitochondrial nitric oxide synthase, leading to inhibition of the respiratory chain, generation of excess superoxide, peroxynitrite production and nitrosative damage. We have measured the radioprotective effects of a nitric oxide synthase antagonist (AMT) versus a free radical scavenger (4-amino-TEMPO) using electrochemical detection of nitric oxide and peroxynitrite. To enhance their efficacy, we have conjugated these compounds to peptides and peptide isosteres - derived from the antibiotic gramicidin S - that target the mitochondria. The targeting ability of these peptidyl conjugates was measured using quantitative mass spectrometry. © The Royal Society of Chemistry.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
1 January 2007 |
Date Type: |
Publication |
Journal or Publication Title: |
Organic and Biomolecular Chemistry |
Volume: |
5 |
Number: |
2 |
Page Range: |
307 - 309 |
DOI or Unique Handle: |
10.1039/b613334g |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
1477-0520 |
MeSH Headings: |
Animals; Cyclic N-Oxides--chemistry; Electrochemistry; Gramicidin--chemistry; Mass Spectrometry; Mitochondria--metabolism; Models, Chemical; Nitric Oxide--chemistry; Nitric Oxide Synthase--antagonists & inhibitors; Peptides--chemistry; Peroxynitrous Acid--chemistry; Submitochondrial Particles--chemistry; Superoxides |
Other ID: |
NLM NIHMS264267, NLM PMC3032592 |
PubMed Central ID: |
PMC3032592 |
PubMed ID: |
17205174 |
Date Deposited: |
07 Jul 2014 16:22 |
Last Modified: |
02 Feb 2019 15:55 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/22177 |
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