Asymmetric alkylation of aromatic aldehydes with diethylzinc catalyzed by a fluorous BINOL-Ti complex in an organic and fluorous biphase system

Nakamura, Y and Takeuchi, S and Ohgo, Y and Curran, DP (2000) Asymmetric alkylation of aromatic aldehydes with diethylzinc catalyzed by a fluorous BINOL-Ti complex in an organic and fluorous biphase system. Tetrahedron Letters, 41 (1). 57 - 60. ISSN 0040-4039

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Abstract

Fluorous chiral BINOL ((R)-FBINOL) was prepared by short reaction steps in good overall yield and was applied to the catalytic asymmetric alkylation in a toluene and FC-72 biphase system. The (R)-FBINOL-Ti complex in the FC-72 phase was consecutively reused in the biphase system and the enantioselectivity was still higher than 80% ee at the 5th reaction.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Nakamura, Y Takeuchi, S Ohgo, Y Curran, DP curran@pitt.edu CURRAN
Date:	1 January 2000
Date Type:	Publication
Journal or Publication Title:	Tetrahedron Letters
Volume:	41
Number:	1
Page Range:	57 - 60
DOI or Unique Handle:	10.1016/s0040-4039(99)01999-1
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0040-4039
Date Deposited:	25 Feb 2014 15:35
Last Modified:	15 Oct 2017 07:55
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/20633

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