Lazo, JS and Wipf, P
(2000)
Combinatorial chemistry and contemporary pharmacology.
Journal of Pharmacology and Experimental Therapeutics, 293 (3).
705 - 709.
ISSN 0022-3565
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Abstract
Both solid- and liquid-phase combinatorial chemistry have emerged as powerful tools for identifying pharmacologically active compounds and optimizing the biological activity of a lead compound. Complementary high- throughput in vitro assays are essential for compound evaluation. Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets. Integration of combinatorial chemistry with contemporary pharmacology now represents an important factor in drug discovery and development.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
1 June 2000 |
Date Type: |
Publication |
Journal or Publication Title: |
Journal of Pharmacology and Experimental Therapeutics |
Volume: |
293 |
Number: |
3 |
Page Range: |
705 - 709 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0022-3565 |
Article Type: |
Review |
MeSH Headings: |
Combinatorial Chemistry Techniques; Peptide Library; Pharmacology |
PubMed ID: |
10869367 |
Date Deposited: |
27 Feb 2014 16:51 |
Last Modified: |
02 Feb 2019 15:56 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/20625 |
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