Du, W and Curran, DP and Bevins, RL and Zimmer, SG and Zhang, J and Burke, TG
(2002)
Synthesis and evaluation of a novel E-ring modified α-hydroxy keto ether analogue of camptothecin.
Bioorganic and Medicinal Chemistry, 10 (1).
103 - 110.
ISSN 0968-0896
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Abstract
The synthesis of a novel E-ring modified keto ether analogue of camptothecin and homocamptothecin by the cascade radical annulation route is reported. The analogue, Du1441, is an isomer of homocamptothecin, but includes the α-hydroxy carbonyl functionality that camptothecin possesses and homocamptothecin lacks. Despite these similarities, the new keto ether analogue is inactive in cell assays, and implications for the structure/activity relationship are discussed. Copyright © 2001 Elsevier Science Ltd.
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Details
Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
---|
Du, W | | | | Curran, DP | curran@pitt.edu | CURRAN | | Bevins, RL | | | | Zimmer, SG | | | | Zhang, J | | | | Burke, TG | | | |
|
Date: |
1 January 2002 |
Date Type: |
Publication |
Journal or Publication Title: |
Bioorganic and Medicinal Chemistry |
Volume: |
10 |
Number: |
1 |
Page Range: |
103 - 110 |
DOI or Unique Handle: |
10.1016/s0968-0896(01)00252-8 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0968-0896 |
MeSH Headings: |
Antineoplastic Agents, Phytogenic--chemical synthesis; Antineoplastic Agents, Phytogenic--pharmacology; Camptothecin--analogs & derivatives; Camptothecin--chemical synthesis; Camptothecin--pharmacology; Chromatography, High Pressure Liquid; Ethers--chemistry; Humans; Molecular Structure; Spectrum Analysis; Tumor Cells, Cultured |
PubMed ID: |
11738612 |
Date Deposited: |
13 Feb 2014 19:25 |
Last Modified: |
02 Feb 2019 16:58 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/20520 |
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