Curran, DP and Du, W
(2002)
Palladium-promoted cascade reactions of isonitriles and 6-iodo-N-propargylpyridones: Synthesis of mappicines, camptothecins, and homocamptothecins.
Organic Letters, 4 (19).
3215 - 3218.
ISSN 1523-7060
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Abstract
Ambient-temperature reactions of electron-rich aryl isonitriles with substituted 6-iodo-N-propargylpyridones in the presence of silver carbonate and palladium acetate produce 11H-indolizino[1,2-b]quinolin-9-ones in good to excellent yield. Experimental evidence suggests that the process occurs though organopalladium rather than radical intermediates. It is applied to synthesis analogues of mappicine and camptothecin, including the silatecans DB-67 and DB-91 (homo-DB-67).
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Details
| Item Type: |
Article
|
| Status: |
Published |
| Creators/Authors: |
|
| Date: |
19 September 2002 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Organic Letters |
| Volume: |
4 |
| Number: |
19 |
| Page Range: |
3215 - 3218 |
| DOI or Unique Handle: |
10.1021/ol026408d |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Refereed: |
Yes |
| ISSN: |
1523-7060 |
| MeSH Headings: |
Alkaloids--chemical synthesis; Camptothecin--analogs & derivatives; Camptothecin--chemical synthesis; Catalysis; Cross-Linking Reagents; Nitriles--chemistry; Palladium--chemistry |
| PubMed ID: |
12227752 |
| Date Deposited: |
12 Feb 2014 22:56 |
| Last Modified: |
29 Jan 2019 15:55 |
| URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/20489 |
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