Wipf, P and Hopkins, TD and Jung, JK and Rodriguez, S and Birmingham, A and Southwick, EC and Lazo, JS and Powis, G
(2001)
New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead.
Bioorganic and Medicinal Chemistry Letters, 11 (19).
2637 - 2641.
ISSN 0960-894X
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Abstract
Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin-thioredoxin reductase redox system. The most potent compound in this series inhibited thioredoxin with an IC50 of 350 nM, and many derivatives showed low micromolar activities for growth inhibition against two breast cancer cell lines. © 2001 Elsevier Science Ltd. All rights reserved.
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Details
Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
---|
Wipf, P | pwipf@pitt.edu | PWIPF | | Hopkins, TD | | | | Jung, JK | | | | Rodriguez, S | | | | Birmingham, A | | | | Southwick, EC | | | | Lazo, JS | | | | Powis, G | | | |
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Date: |
8 October 2001 |
Date Type: |
Publication |
Journal or Publication Title: |
Bioorganic and Medicinal Chemistry Letters |
Volume: |
11 |
Number: |
19 |
Page Range: |
2637 - 2641 |
DOI or Unique Handle: |
10.1016/s0960-894x(01)00525-x |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0960-894X |
MeSH Headings: |
Antineoplastic Agents--chemical synthesis; Antineoplastic Agents--chemistry; Antineoplastic Agents--pharmacology; Cell Division--drug effects; Dioxanes--chemical synthesis; Dioxanes--chemistry; Dioxanes--pharmacology; Drug Screening Assays, Antitumor; Epoxy Compounds--chemical synthesis; Epoxy Compounds--chemistry; Epoxy Compounds--pharmacology; Humans; Naphthalenes; Naphthoquinones--chemical synthesis; Naphthoquinones--chemistry; Naphthoquinones--pharmacology; Spiro Compounds--chemical synthesis; Spiro Compounds--chemistry; Spiro Compounds--pharmacology; Thioredoxin-Disulfide Reductase--antagonists & inhibitors; Thioredoxins--antagonists & inhibitors; Tumor Cells, Cultured |
PubMed ID: |
11551767 |
Date Deposited: |
13 Feb 2014 18:57 |
Last Modified: |
12 Jun 2021 22:55 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/20482 |
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