Microwave Heating Effects Rapid and Selective Decarboalkoxylation of Mono-Alkylated Malonates and β-Ketoesters

Curran, DP and Zhang, Q (2003) Microwave Heating Effects Rapid and Selective Decarboalkoxylation of Mono-Alkylated Malonates and β-Ketoesters. Advanced Synthesis and Catalysis, 345 (3). 329 - 332. ISSN 1615-4150

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Abstract

Brief microwave irradiation of mono-alkylated malonates and β-ketoesters at 160-200 °C in wet DMF induces smooth and selective decarboalkoxylation. Observations suggest that this reaction occurs by nucleophilic attack of water at the ester carbonyl carbon (hydrolysis) followed by decarboxylation of the resulting acid. The process occurs despite the absence of traditional acid, base or nucleophile catalysts or reagents.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Curran, DP curran@pitt.edu CURRAN Zhang, Q
Date:	1 March 2003
Date Type:	Publication
Journal or Publication Title:	Advanced Synthesis and Catalysis
Volume:	345
Number:	3
Page Range:	329 - 332
DOI or Unique Handle:	10.1002/adsc.200390033
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	1615-4150
Date Deposited:	07 Feb 2014 00:00
Last Modified:	02 Feb 2019 15:58
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/20460

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