Cascade 4+1 radical annulations of 2,6-disubstituted phenyl isonitriles with N-propargyl-6-iodopyridones: Scope, mechanism and regioselective synthesis of 7,9-disubstituted camptothecin analogs

Du, W and Curran, DP (2003) Cascade 4+1 radical annulations of 2,6-disubstituted phenyl isonitriles with N-propargyl-6-iodopyridones: Scope, mechanism and regioselective synthesis of 7,9-disubstituted camptothecin analogs. Synlett (9 SPEC). 1299 - 1302. ISSN 0936-5214

Plain Text (licence) Available under License : See the attached license file. Download (1kB)

Abstract

The reaction of o,o′-dialkyl-substituted aryl isonitriles with N-propargyl-6-iodopyridones provides 11H-indolizino[1,2-b]quinolin-9-ones with significant regioselectivity in favor of the more crowded product. The usefulness of the method is illustrated with a regioselective synthesis of (20S)-7-trimethylsilyl-9-isopropyl camptothecin.

---

Share

Citation/Export:	Select format... Citation - Text Citation - HTML Endnote BibTex Dublin Core OpenURL MARC (ISO 2709) METS MODS EP3 XML Reference Manager Refer
Social Networking:	Share |

---

Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Du, W Curran, DP curran@pitt.edu CURRAN
Date:	1 January 2003
Date Type:	Publication
Journal or Publication Title:	Synlett
Number:	9 SPEC
Page Range:	1299 - 1302
DOI or Unique Handle:	10.1055/s-2003-40327
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0936-5214
Date Deposited:	31 Jan 2014 21:23
Last Modified:	07 Jul 2022 02:55
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/20443

---

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

---

Actions (login required)

View Item