Lazo, JS and Wipf, P
(2002)
Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways.
Oncology Research, 13 (6-10).
347 - 352.
ISSN 0965-0407
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Abstract
Small molecules provide exceptionally useful tools for probing signaling targets relevant for cancer and stem cell differentiation. In contrast to genetic approaches, the application of small molecules generally offers a graded and reversible disruption of a particular pathway. The vast array of theoretical chemical entities that exist in the chemical universe are now becoming available through the production and distribution of chemical libraries generated by both traditional and combinatorial methods, which are suitable for pharmacological use. Convenient and inexpensive cell-free and cell-based assays can be used to identify chemicals that exhibit desirable antisignaling properties. We illustrate a model of how agents targeted against signaling macromolecules involved in cancer, namely dual specificity protein phosphatases, can be identified.
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Details
Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
|
Date: |
1 January 2002 |
Date Type: |
Publication |
Journal or Publication Title: |
Oncology Research |
Volume: |
13 |
Number: |
6-10 |
Page Range: |
347 - 352 |
DOI or Unique Handle: |
10.3727/096504003108748555 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0965-0407 |
MeSH Headings: |
Antineoplastic Agents--pharmacology; Cell Cycle--drug effects; Cell Transformation, Neoplastic--metabolism; Enzyme Inhibitors--pharmacology; Humans; Models, Biological; Models, Molecular; Signal Transduction--physiology; cdc25 Phosphatases--classification; cdc25 Phosphatases--drug effects |
PubMed ID: |
12725524 |
Date Deposited: |
30 Jan 2014 18:25 |
Last Modified: |
04 Jul 2020 14:55 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/20433 |
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