Convergent approach to (E)-alkene and cyclopropane peptide isosteres

Wipf, P and Xiao, J (2005) Convergent approach to (E)-alkene and cyclopropane peptide isosteres. Organic Letters, 7 (1). 103 - 106. ISSN 1523-7060

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Abstract

(Chemical Equation Presented) Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition-cyclopropanation methodologies, respectively. These new peptide mimetics can serve as β-turn promoters.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Wipf, P pwipf@pitt.edu PWIPF Xiao, J
Date:	6 January 2005
Date Type:	Publication
Journal or Publication Title:	Organic Letters
Volume:	7
Number:	1
Page Range:	103 - 106
DOI or Unique Handle:	10.1021/ol0477529
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	1523-7060
MeSH Headings:	Alkenes--chemistry; Cyclopropanes--chemistry; Models, Molecular; Molecular Structure; Peptides--chemistry; X-Ray Diffraction
PubMed ID:	15624988
Date Deposited:	30 Jan 2014 18:12
Last Modified:	02 Feb 2019 15:57
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/20408

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