Three-component synthesis of α,β-cyclopropyl-γ-amino acids

Wipf, P and Stephenson, CRJ (2005) Three-component synthesis of α,β-cyclopropyl-γ-amino acids. Organic Letters, 7 (6). 1137 - 1140. ISSN 1523-7060

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Abstract

(Chemical Equation Presented) The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into α,β-cyclopropyl-γ-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes. © 2005 American Chemical Society.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Wipf, P pwipf@pitt.edu PWIPF Stephenson, CRJ
Date:	17 March 2005
Date Type:	Publication
Journal or Publication Title:	Organic Letters
Volume:	7
Number:	6
Page Range:	1137 - 1140
DOI or Unique Handle:	10.1021/ol0501525
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	1523-7060
MeSH Headings:	Alkynes--chemistry; Amino Acids--chemical synthesis; Amino Acids--chemistry; Catalysis; Cyclopropanes--chemical synthesis; Cyclopropanes--chemistry; Molecular Structure; Stereoisomerism
PubMed ID:	15760158
Date Deposited:	17 Dec 2013 15:29
Last Modified:	02 Feb 2019 15:57
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/20182

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