Wipf, P and Halter, RJ
(2005)
Chemistry and biology of wortmannin.
Organic and Biomolecular Chemistry, 3 (11).
2053 - 2061.
ISSN 1477-0520
![[img]](http://d-scholarship-dev.library.pitt.edu/style/images/fileicons/text_plain.png) |
Plain Text (licence)
Available under License : See the attached license file.
Download (1kB)
|
Abstract
Recent synthetic and biological studies of the viridin class of steroidal furans have revealed multiple opportunities for fundamental discoveries as well as advanced drug design. Wortmannin is a potent enzyme inhibitor that binds to the ATP site of important regulatory kinases such as PI-3 kinase and Polo-like kinase. The natural product shares a unique mechanism-based biological activation pathway with other viridins. Furthermore, while there have been several encouraging approaches toward the total synthesis of these compounds, there is still ample room for improvements in synthetic strategies and tactics, and the development of structurally simplified analogs that exert more specific biological effects and are devoid of toxicity issues that have thwarted the clinical development of the parent compounds. © The Royal Society of Chemistry 2005.
Share
Citation/Export: |
|
Social Networking: |
|
Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
7 June 2005 |
Date Type: |
Publication |
Journal or Publication Title: |
Organic and Biomolecular Chemistry |
Volume: |
3 |
Number: |
11 |
Page Range: |
2053 - 2061 |
DOI or Unique Handle: |
10.1039/b504418a |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
1477-0520 |
MeSH Headings: |
Adenosine Triphosphate--metabolism; Androstadienes--chemistry; Androstadienes--metabolism; Enzyme Inhibitors--chemistry; Enzyme Inhibitors--metabolism; Models, Molecular; Phosphatidylinositol 3-Kinases--antagonists & inhibitors; Phosphatidylinositol 3-Kinases--chemistry; Phosphatidylinositol 3-Kinases--metabolism |
PubMed ID: |
15917886 |
Date Deposited: |
12 Nov 2013 17:17 |
Last Modified: |
02 Feb 2019 15:56 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/19978 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Altmetric.com
Actions (login required)
![View Item View Item](/style/images/action_view.png) |
View Item |