Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

Wipf, P and Lynch, SM and Powis, G and Birmingham, A and Englund, EE (2005) Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system. Organic and Biomolecular Chemistry, 3 (21). 3880 - 3882. ISSN 1477-0520

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Abstract

A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile. © The Royal Society of Chemistry 2005.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Wipf, P pwipf@pitt.edu PWIPF Lynch, SM Powis, G Birmingham, A Englund, EE
Date:	7 November 2005
Date Type:	Publication
Journal or Publication Title:	Organic and Biomolecular Chemistry
Volume:	3
Number:	21
Page Range:	3880 - 3882
DOI or Unique Handle:	10.1039/b510718k
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	1477-0520
MeSH Headings:	Antineoplastic Agents--chemical synthesis; Antineoplastic Agents--pharmacology; Cell Line, Tumor; Cell Proliferation--drug effects; Drug Screening Assays, Antitumor; Humans; Naphthalenes--chemistry; Naphthalenes--pharmacology; Prodrugs--chemical synthesis; Prodrugs--pharmacology; Solubility; Spiro Compounds--chemistry; Spiro Compounds--pharmacology; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase--antagonists & inhibitors; Thioredoxins--antagonists & inhibitors
PubMed ID:	16240002
Date Deposited:	30 Oct 2013 16:48
Last Modified:	02 Feb 2019 15:56
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/19936

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