Dandapani, S and Curran, DP
(2004)
Separation-friendly Mitsunobu reactions: A microcosm of recent developments in separation strategies.
Chemistry - A European Journal, 10 (13).
3130 - 3138.
ISSN 0947-6539
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Abstract
The Mitsunobu reaction is famous for its scope and power, but infamous for its separation headaches. Typically, the target product is enticed away from the reagent-derived byproducts by careful chromatography. The use of polymer-bound Mitsunobu reagents solves only half of the problem, because polymer-bound diethyl azodicarboxylate (DEAD) and phosphine reagents cannot be employed simultaneously. This article classifies, compares, and contrasts various emerging strategies for product isolation in Mitsunobu reactions. Because so many different strategies have been used, the Mitsunobu reaction is a microcosm for the new field of strategy level separations.
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Details
Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
---|
Dandapani, S | | | | Curran, DP | curran@pitt.edu | CURRAN | |
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Date: |
5 July 2004 |
Date Type: |
Publication |
Journal or Publication Title: |
Chemistry - A European Journal |
Volume: |
10 |
Number: |
13 |
Page Range: |
3130 - 3138 |
DOI or Unique Handle: |
10.1002/chem.200400363 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0947-6539 |
Article Type: |
Review |
MeSH Headings: |
Alcohols--chemistry; Alcohols--isolation & purification; Azo Compounds--chemistry; Azo Compounds--isolation & purification; Chlorophenols--chemistry; Chlorophenols--isolation & purification; Combinatorial Chemistry Techniques--methods; Dicarboxylic Acids--chemistry; Dicarboxylic Acids--isolation & purification; Hydrazines--chemistry; Hydrazines--isolation & purification; Organophosphorus Compounds--chemistry; Organophosphorus Compounds--isolation & purification |
PubMed ID: |
15224321 |
Date Deposited: |
18 Oct 2013 17:38 |
Last Modified: |
15 Oct 2017 06:55 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/19888 |
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