Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form
D-Scholarship @ Pitt Banner and Links to Homepage

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B

Keinan, S and Paquette, WD and Skoko, JJ and Beratan, DN and Yang, W and Shinde, S and Johnston, PA and Lazo, JS and Wipf, P (2008) Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. Organic and Biomolecular Chemistry, 6 (18). 3256 - 3263. ISSN 1477-0520

[img] Plain Text (licence)
Available under License : See the attached license file.
Download (1kB)

Abstract

Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E1/2. © 2008 The Royal Society of Chemistry.

Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Keinan, S
Paquette, WD
Skoko, JJ
Beratan, DN
Yang, W
Shinde, S
Johnston, PApaj18@pitt.eduPAJ18
Lazo, JS
Wipf, Ppwipf@pitt.eduPWIPF
Date: 3 October 2008
Date Type: Publication
Journal or Publication Title: Organic and Biomolecular Chemistry
Volume: 6
Number: 18
Page Range: 3256 - 3263
DOI or Unique Handle: 10.1039/b806712k
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1477-0520
MeSH Headings: Cell Line, Tumor; Cell Survival--drug effects; Combinatorial Chemistry Techniques; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors--chemical synthesis; Enzyme Inhibitors--chemistry; Enzyme Inhibitors--pharmacology; Humans; Hydrogen Peroxide; Molecular Structure; Oxidation-Reduction--drug effects; Quinones--chemical synthesis; Quinones--chemistry; Quinones--pharmacology; Structure-Activity Relationship; Substrate Specificity; cdc25 Phosphatases--antagonists & inhibitors; cdc25 Phosphatases--metabolism
Other ID: NLM NIHMS123614, NLM PMC2752828
PubMed Central ID: PMC2752828
PubMed ID: 18802630
Date Deposited: 15 Jul 2013 19:55
Last Modified: 12 Jun 2021 22:55
URI: http://d-scholarship-dev.library.pitt.edu/id/eprint/19276

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

Actions (login required)

View Item View Item