Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: Octahydro-1H-indole carboxylates

Pierce, JG and Kasi, D and Fushimi, M and Cuzzupe, A and Wipf, P (2008) Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: Octahydro-1H-indole carboxylates. Journal of Organic Chemistry, 73 (19). 7807 - 7810. ISSN 0022-3263

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Abstract

(Chemical Equation Presented) A stereoselective approach to polyhydroxylated L-Choi derivatives has been developed. The oxidative cyclization of L-tyrosine was optimized to avoid partial racemization and to allow a more efficient scale-up. © 2008 American Chemical Society.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Pierce, JG Kasi, D Fushimi, M Cuzzupe, A Wipf, P pwipf@pitt.edu PWIPF
Date:	3 October 2008
Date Type:	Publication
Journal or Publication Title:	Journal of Organic Chemistry
Volume:	73
Number:	19
Page Range:	7807 - 7810
DOI or Unique Handle:	10.1021/jo801552j
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0022-3263
MeSH Headings:	Amino Acids--chemical synthesis; Amino Acids--chemistry; Bicyclo Compounds--chemical synthesis; Carboxylic Acids--chemistry; Hydroxylation; Indoles--chemistry; Stereoisomerism; Tyrosine--chemistry
Other ID:	NLM NIHMS86316, NLM PMC2739982
PubMed Central ID:	PMC2739982
PubMed ID:	18767800
Date Deposited:	03 Jul 2013 15:44
Last Modified:	02 Feb 2019 15:57
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/19252

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