Microwave-assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones

Saiz, C and Pizzo, C and Manta, E and Wipf, P and Mahler, SG (2009) Microwave-assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones. Tetrahedron Letters, 50 (8). 901 - 904. ISSN 0040-4039

Plain Text (licence) Available under License : See the attached license file. Download (1kB)

Abstract

A tandem method for the synthesis of 2-hydrazolyl-4-thiazolidinones (5) from commercially available materials in a 3-component reaction has been developed. The reaction connects aldehydes, thiosemicarbazides, and maleic anhydride, effectively assisted by microwave irradiation. The synthesis of a new type of compound, 2-hydrazolyl-5,5-diphenyl-4-thiazolidinone (7), obtained by treatment of thiosemicarbazone with benzil in basic media is also reported. HOMO/LUMO energies, orbital coefficients, and charge distribution were used to explain the proposed reaction mechanism. © 2008 Elsevier Ltd.

---

Share

Citation/Export:	Select format... Citation - Text Citation - HTML Endnote BibTex Dublin Core OpenURL MARC (ISO 2709) METS MODS EP3 XML Reference Manager Refer
Social Networking:	Share |

---

Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Saiz, C Pizzo, C Manta, E Wipf, P pwipf@pitt.edu PWIPF Mahler, SG
Date:	25 February 2009
Date Type:	Publication
Journal or Publication Title:	Tetrahedron Letters
Volume:	50
Number:	8
Page Range:	901 - 904
DOI or Unique Handle:	10.1016/j.tetlet.2008.12.020
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0040-4039
PubMed Central ID:	PMC2743427
PubMed ID:	19756224
Date Deposited:	03 Jul 2013 14:50
Last Modified:	02 Feb 2019 15:57
URI:	http://d-scholarship-dev.library.pitt.edu/id/eprint/19215

---

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

---

Actions (login required)

View Item