Manku, S and Curran, DP
(2005)
Fluorous mixture synthesis of fused-tricyclic hydantoins. Use of a redundant tagging strategy on fluorinated substrates.
Journal of Organic Chemistry, 70 (11).
4470 - 4473.
ISSN 0022-3263
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Abstract
Simple HPLC experiments were used to identify a redundant tagging scheme wherein six different amino acids were tagged with only four fluorous tags. The tagged amino acids were converted to regiosiomeric mixtures of tricyclic hydantoins. Despite the lack of selectivity, the mixtures were demixed and detagged to give 11 individual pure products in just 25 steps. © 2005 American Chemical Society.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
27 May 2005 |
Date Type: |
Publication |
Journal or Publication Title: |
Journal of Organic Chemistry |
Volume: |
70 |
Number: |
11 |
Page Range: |
4470 - 4473 |
DOI or Unique Handle: |
10.1021/jo0502596 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0022-3263 |
MeSH Headings: |
Amino Acids--chemistry; Chemistry, Organic--methods; Chromatography, High Pressure Liquid; Hydantoins--chemical synthesis; Hydantoins--chemistry; Hydrocarbons, Fluorinated--chemical synthesis; Hydrocarbons, Fluorinated--chemistry; Molecular Structure |
PubMed ID: |
15903326 |
Date Deposited: |
03 Jul 2013 14:26 |
Last Modified: |
02 Feb 2019 15:59 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/19214 |
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