Zhang, W and Lu, Y and Chen, CHT and Curran, DP and Geib, S
(2006)
Fluorous synthesis of hydantoin-, piperazinedione-, and benzodiazepinedione-fused tricyclic and tetracyclic ring systems.
European Journal of Organic Chemistry (9).
2055 - 2059.
ISSN 1434-193X
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Abstract
Fluorous proline derivatives generated from one-pot, three-component [3+2] cycloaddition of azomethine ylides are employed in different post-condensation reactions to form hydantoin-, piperazinedione-, and benzodiazepinedione-fused tricyclic and tetracyclic ring systems. High synthetic efficiency is achieved by conducting fast microwave reactions and purification by easy fluorous solid-phase extractions. Methods developed for these novel drug-like heterocyclic compounds can be applied to diversity-oriented library syntheses. © Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
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