Chin-Hong, PV and Husnik, M and Cranston, RD and Colfax, G and Buchbinder, S and Da Costa, M and Darragh, T and Jones, D and Judson, F and Koblin, B and Mayer, KH and Palefsky, JM
(2009)
Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men.
AIDS, 23 (9).
1135 - 1142.
ISSN 0269-9370
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Abstract
OBJECTIVE:: Human papillomavirus (HPV) is a common sexually transmitted agent that causes anogenital cancer and precancer lesions that have an inflammatory infiltrate, may be friable and bleed. Our aim was to determine the association between anal HPV infection and HIV acquisition. DESIGN:: A prospective cohort study. METHODS:: We recruited 1409 HIV-negative men who have sex with men from a community-based setting in Boston, Denver, New York and San Francisco. We used Cox proportional hazards regression modeling and assessed the independent association of HPV infection with the rate of acquisition of HIV infection. RESULTS:: Of 1409 participants contributing 4375 person-years of follow-up, 51 HIV-seroconverted. The median number of HPV types in HPV-infected HIV-seroconverters was 2 (interquartile range 1-3) at the time of HIV seroconversion. After adjustment for sexual activity, substance use, occurrence of other sexually transmitted infections and demographic variables, there was evidence (P = 0.002) for the effect of infection with at least two HPV types (hazard ratio 3.5, 95% confidence interval 1.2-10.6) in HIV seroconversion. CONCLUSION:: Anal HPV infection is independently associated with HIV acquisition. Studies that incorporate high-resolution anoscopy to more accurately identify HPV-associated disease are needed to determine the relationship between HPV-associated disease and HIV seroconversion. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
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Chin-Hong, PV | | | | Husnik, M | | | | Cranston, RD | rdc27@pitt.edu | RDC27 | | Colfax, G | | | | Buchbinder, S | | | | Da Costa, M | | | | Darragh, T | | | | Jones, D | | | | Judson, F | | | | Koblin, B | | | | Mayer, KH | | | | Palefsky, JM | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Center for LGBT Health Research |
Date: |
1 June 2009 |
Date Type: |
Publication |
Journal or Publication Title: |
AIDS |
Volume: |
23 |
Number: |
9 |
Page Range: |
1135 - 1142 |
DOI or Unique Handle: |
10.1097/qad.0b013e32832b4449 |
Schools and Programs: |
School of Public Health > Infectious Diseases and Microbiology |
Refereed: |
Yes |
ISSN: |
0269-9370 |
MeSH Headings: |
Adult; Anus Diseases--virology; Boston; HIV Seropositivity--transmission; HIV Seropositivity--virology; HIV-1; Homosexuality, Male; Humans; Male; Middle Aged; New York; Papillomavirus Infections--transmission; Papillomavirus Infections--virology; Precancerous Conditions--virology; Prospective Studies; RNA, Viral; San Francisco |
PubMed ID: |
19390418 |
Date Deposited: |
25 Jun 2013 19:38 |
Last Modified: |
02 Feb 2019 16:57 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/18975 |
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