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Amide bond formation with a new fluorous carbodiimide: Separation by reverse fluorous solid-phase extraction

Del Pozo, C and Keller, AI and Nagashima, T and Curran, DP (2007) Amide bond formation with a new fluorous carbodiimide: Separation by reverse fluorous solid-phase extraction. Organic Letters, 9 (21). 4167 - 4170. ISSN 1523-7060

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Abstract

A new fluorous carbodiimide is introduced along with a convenient procedure for amide coupling reactions. Reactions of acids and amines under standard conditions for carbodiimide couplings, followed by simple reverse fluorous solid-phase extraction (FSPE) over standard silica gel, provide the target amide products in good yields and purities. The use of HFE-7100 as a fluorous solvent is crucial for the success of the reverse FSPE. © 2007 American Chemical Society.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Del Pozo, C
Keller, AI
Nagashima, T
Curran, DPcurran@pitt.eduCURRAN
Date: 11 October 2007
Date Type: Publication
Journal or Publication Title: Organic Letters
Volume: 9
Number: 21
Page Range: 4167 - 4170
DOI or Unique Handle: 10.1021/ol701631m
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1523-7060
MeSH Headings: Amides--chemical synthesis; Amides--chemistry; Amines--chemistry; Carbodiimides--chemical synthesis; Carbodiimides--chemistry; Hydrocarbons, Fluorinated--chemistry; Molecular Structure; Solid Phase Extraction--instrumentation; Solid Phase Extraction--methods
PubMed ID: 17887689
Date Deposited: 08 Apr 2013 17:18
Last Modified: 02 Feb 2019 15:59
URI: http://d-scholarship-dev.library.pitt.edu/id/eprint/18198

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