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Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts

Eiseman, JL and Bai, L and Jung, WH and Moura-Letts, G and Day, BW and Curran, DP (2008) Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts. Journal of Medicinal Chemistry, 51 (21). 6650 - 6653. ISSN 0022-2623

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Abstract

Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts. © 2008 American Chemical Society.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Eiseman, JLjle9@pitt.eduJLE9
Bai, L
Jung, WH
Moura-Letts, G
Day, BW
Curran, DPcurran@pitt.eduCURRAN
Date: 13 November 2008
Date Type: Publication
Journal or Publication Title: Journal of Medicinal Chemistry
Volume: 51
Number: 21
Page Range: 6650 - 6653
DOI or Unique Handle: 10.1021/jm800979v
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0022-2623
MeSH Headings: Animals; Body Weight--drug effects; Breast Neoplasms--drug therapy; Breast Neoplasms--pathology; Cell Line, Tumor; Disease Progression; Female; Humans; Macrolides--chemical synthesis; Macrolides--chemistry; Macrolides--therapeutic use; Mice; Xenograft Model Antitumor Assays
Other ID: NLM NIHMS86529, NLM PMC2627582
PubMed Central ID: PMC2627582
PubMed ID: 18839939
Date Deposited: 01 Mar 2013 15:47
Last Modified: 02 Feb 2019 15:58
URI: http://d-scholarship-dev.library.pitt.edu/id/eprint/17615

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