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Photonic crystal glucose-sensing material for noninvasive monitoring of glucose in tear fluid

Alexeev, VL and Das, S and Finegold, DN and Asher, SA (2004) Photonic crystal glucose-sensing material for noninvasive monitoring of glucose in tear fluid. Clinical Chemistry, 50 (12). 2353 - 2360. ISSN 0009-9147

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Abstract

Background: We recently developed a photonic crystal glucose-sensing material (Alexeev et al., Anal Chem 2003;75:2316-23), which consists of a crystalline colloidal array embedded within a polymer network of a polyacrylamide-poly(ethylene glycol) hydrogel with pendent phenylboronic acid groups. The aim of the present work was to improve this approach for application to noninvasive or minimally invasive monitoring of glucose. Methods: We used new boronic acid derivatives such as 4-amino-3-fluorophenylboronic acid and 4-carboxy-3-fluorophenylboronic acid as the molecular recognition elements to achieve sensing at physiologic pH values. Results: The improved photonic glucose-sensing material sensed glucose in the range of the 100 μmol/L concentrations found in tear fluid. The detection limits were ∼1 μmol/L in synthetic tear fluid. The visually evident diffraction color shifted across the entire visible spectral region from red to blue over the physiologically relevant tear-fluid glucose concentrations. This sensing material is selective for glucose over galactose, mannose, and fructose. Conclusions: These new glucose sensors have properties appropriate for use in such glucose-sensing applications as ocular inserts or diagnostic contact lenses for patients with diabetes mellitus. © 2004 American Association for Clinical Chemistry.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Alexeev, VL
Das, S
Finegold, DN
Asher, SAasher@pitt.eduASHER
Date: 1 December 2004
Date Type: Publication
Journal or Publication Title: Clinical Chemistry
Volume: 50
Number: 12
Page Range: 2353 - 2360
DOI or Unique Handle: 10.1373/clinchem.2004.039701
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0009-9147
MeSH Headings: Blood Glucose--analysis; Boronic Acids--chemistry; Colloids; Contact Lenses; Crystallization; Fructose--analysis; Galactose--analysis; Glucose--analysis; Glucose--chemistry; Humans; Hydrogels; Mannose--analysis; Microspheres; Sensitivity and Specificity; Tears--chemistry
PubMed ID: 15459093
Date Deposited: 08 Feb 2013 21:20
Last Modified: 02 Feb 2019 14:56
URI: http://d-scholarship-dev.library.pitt.edu/id/eprint/17189

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