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Polymerized crystalline colloidal array chemical-sensing materials for detection of lead in body fluids

Asher, SA and Peteu, SF and Reese, CE and Lin, MX and Finegold, D (2002) Polymerized crystalline colloidal array chemical-sensing materials for detection of lead in body fluids. Analytical and Bioanalytical Chemistry, 373 (7). 632 - 638. ISSN 1618-2642

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Abstract

We have developed intelligent polymerized crystalline colloidal array (IPCCA) chemical-sensing materials for detection of Pb2+ in high ionic-strength environments such as body fluids with a detection limit of <500 nmol L-1 Pb2+ (100 ppb). This IPCCA lead sensor consists of a mesoscopically periodic array of colloidal particles polymerized into an acrylamide hydrogel. The array Bragg-diffracts light in the visible spectral region because of the periodic spacing of the colloidal particles. This material also contains a crown ether chelating agent for Pb2+. Chelation of Pb2+ by the IPCCA in low-ionic-strength solutions results in a Donnan potential that swells the gel, which red-shifts the diffracted light in proportion to the Pb2+ concentration. At high ionic strength the Donnan potential is, unfortunately, swamped and no static response occurs for these sensors. We demonstrate, however, that we can determine Pb2+ at high ionic strength by incubating these IPCCA in a sample solution and then measuring their transient response on exposure to pure water. The non-complexed ions diffuse from the IPCCA faster than the bound Pb2+. The resulting transient IPCCA diffraction red-shift is proportional to the concentration of Pb2+ in the sample. These IPCCA sensors can thus be used as sensing materials in optrodes to determine Pb2+ in high-ionic-strength solutions such as body fluids.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Asher, SAasher@pitt.eduASHER
Peteu, SF
Reese, CE
Lin, MX
Finegold, D
Date: 1 January 2002
Date Type: Publication
Journal or Publication Title: Analytical and Bioanalytical Chemistry
Volume: 373
Number: 7
Page Range: 632 - 638
DOI or Unique Handle: 10.1007/s00216-002-1366-z
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1618-2642
MeSH Headings: Acrylamide; Animals; Blood Chemical Analysis--methods; Body Fluids--chemistry; Cattle; Chemistry Techniques, Analytical--methods; Colloids--chemistry; Crystallization; Fetal Blood--chemistry; Hydrogel; Lead--analysis; Lead--blood; Osmolar Concentration; Polymers--chemistry; Scattering, Radiation; Sensitivity and Specificity; Water--chemistry
PubMed ID: 12185576
Date Deposited: 23 Jan 2013 21:47
Last Modified: 12 Jun 2021 23:55
URI: http://d-scholarship-dev.library.pitt.edu/id/eprint/17152

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