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The effects of long-term spinal cord injury on mechanical properties of the rat urinary bladder

Toosi, KK and Nagatomi, J and Chancellor, MB and Sacks, MS (2008) The effects of long-term spinal cord injury on mechanical properties of the rat urinary bladder. Annals of Biomedical Engineering, 36 (9). 1470 - 1480. ISSN 0090-6964

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Abstract

We have demonstrated that bladder wall tissue in spinal cord injury (SCI) rats at 10 days post-injury is more compliant and accompanied by changes in material class from orthotropic to isotropic as compared to normal tissue. The present study examined the long-term effects (3-, 6-, and 10-weeks) post-SCI on the mechanical properties of bladder wall tissues, along with quantitative changes in smooth muscle orientation and collagen and elastin content. Bladder wall compliance (defined as det(F) - 1 under an equi-biaxial stress state of 100 kPa, where F is the deformation gradient tensor) was found to be significantly greater at 3- and 6-weeks (0.873 ± 0.092 and 0.864 ± 0.112, respectively) when compared to the normal bladders (0.260 ± 0.028), but at 10 weeks the compliance reduced (0.389 ± 0.061) to near that of normal bladders. This trend in mechanical compliance closely paralleled the collagen/elastin ratio. Moreover, changes in material class, assessed using a graphical technique, correlated closely with quantitative changes in smooth muscle fiber orientation. The results of the present study provide the first evidence that, while similarities exist between acute and chronic responses of the urinary bladder wall tissue to SCI, the overall alterations are distinct, result in profound and complex time dependent changes in bladder wall structure, and will lay the basis for simulations of the bladder wall disease process. © 2008 Biomedical Engineering Society.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Toosi, KKkkt6@pitt.eduKKT14
Nagatomi, J
Chancellor, MB
Sacks, MS
Centers: Other Centers, Institutes, Offices, or Units > Human Engineering Research Laboratories
Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Date: 1 September 2008
Date Type: Publication
Journal or Publication Title: Annals of Biomedical Engineering
Volume: 36
Number: 9
Page Range: 1470 - 1480
DOI or Unique Handle: 10.1007/s10439-008-9525-9
Schools and Programs: School of Health and Rehabilitation Sciences > Rehabilitation Science and Technology
School of Medicine > Urology
Swanson School of Engineering > Bioengineering
Refereed: Yes
ISSN: 0090-6964
MeSH Headings: Animals; Collagen--metabolism; Elastin--metabolism; Female; Muscle, Smooth--metabolism; Muscle, Smooth--physiopathology; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries--metabolism; Spinal Cord Injuries--physiopathology; Stress, Mechanical; Time Factors; Urinary Bladder--metabolism; Urinary Bladder--physiopathology
PubMed ID: 18622703
Date Deposited: 02 Nov 2012 21:06
Last Modified: 05 Jan 2021 12:55
URI: http://d-scholarship-dev.library.pitt.edu/id/eprint/16229

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