Wang, CC and Nagatomi, J and Toosi, KK and Yoshimura, N and Hsieh, JH and Chancellor, MB and Sacks, MS
(2009)
Diabetes-induced Alternations in Biomechanical Properties of Urinary Bladder Wall in Rats.
Urology, 73 (4).
911 - 915.
ISSN 0090-4295
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Abstract
Objectives: To determine whether diabetes mellitus and the associated changes in bladder function will trigger bladder wall tissue remodeling and concomitant alterations in the mechanical properties. We investigated the time course of changes in function and mechanical properties of diabetic and diuretic rat bladders using both in vivo and in vitro techniques. Methods: Cystometry was performed at 2, 4, and 8 weeks on female Sprague-Dawley rats that had received either a single injection of streptozotocin (65 mg/kg intraperitoneally) or 5% sucrose in drinking water for the duration of the experiments. At each point, the biaxial mechanical properties of 10 × 10-mm tissue specimens obtained from the posterior part of bladder wall were quantified. The changes in overall tissue compliance and mechanical anisotropy as a function of time were examined. Results: Both diabetic and diuretic conditions led to increases in bladder weight, bladder capacity, and in vivo compliance compared with the controls at all points tested. Under biaxial loading, all bladder wall tissues exhibited a nonlinear stress-strain relationship and mechanical anisotropy, with greater tissue compliance in the circumferential direction than in the longitudinal direction. Although the compliance of the bladder wall increased progressively and synchronously in both diabetic and diuretic bladders for ≤4 weeks, only the diabetic bladders continued to increase the compliance for ≤8 weeks (diabetic 0.64 ± 0.04 vs diuretic 0.48 ± 0.05, P = .03). Conclusions: The results of our study have shown that diuresis mainly contributes to the "early" changes of mechanical properties of the bladder, with diabetes inducing additional "late" changes of mechanical properties of the rat bladders after 4 weeks. © 2009 Elsevier Inc. All rights reserved.
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Details
Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID |
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Wang, CC | | | | Nagatomi, J | | | | Toosi, KK | kkt6@pitt.edu | KKT14 | | Yoshimura, N | nyos@pitt.edu | NYOS | | Hsieh, JH | | | | Chancellor, MB | | | | Sacks, MS | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Human Engineering Research Laboratories |
Date: |
1 April 2009 |
Date Type: |
Publication |
Journal or Publication Title: |
Urology |
Volume: |
73 |
Number: |
4 |
Page Range: |
911 - 915 |
DOI or Unique Handle: |
10.1016/j.urology.2008.11.026 |
Schools and Programs: |
School of Health and Rehabilitation Sciences > Rehabilitation Science and Technology School of Medicine > Urology Swanson School of Engineering > Bioengineering |
Refereed: |
Yes |
ISSN: |
0090-4295 |
MeSH Headings: |
Animals; Biomechanics; Diabetes Mellitus, Experimental--physiopathology; Female; Rats; Rats, Sprague-Dawley; Urinary Bladder--physiopathology |
Other ID: |
NLM NIHMS107624, NLM PMC2728502 |
PubMed Central ID: |
PMC2728502 |
PubMed ID: |
19168204 |
Date Deposited: |
02 Nov 2012 21:07 |
Last Modified: |
05 Jan 2021 11:55 |
URI: |
http://d-scholarship-dev.library.pitt.edu/id/eprint/16228 |
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